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Boston University Superfund Research Program

 
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Projects and Cores

Project 1: Neurotoxic Effects of PCE Exposure During Gestation and Childhood

Project Leader, Ann Aschengrau (Boston University School of Public Health)
Studying effects on neurodevelopment of a population exposed to perchloroethylene (PCE, a peroxisome proliferator) in drinking water.

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Project 2: Analyzing Patterns in Epidemiologic and Toxicologic Data

Project Leader, Tom Webster (Boston University School of Public Health)
Developing improved methods for mapping epidemiologic data on reproductive and developmental outcomes while adjusting for known risk factors.

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Project 3: Nuclear Receptors and Gonadal Toxicity of Xenochemicals

Project Leader, David J. Waxman (Boston University, Department of Biology)
Studying exposure to xenoestrogens and other endocrine-disrupting chemicals associated with a variety of developmental and reproductive abnormalities.

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Project 4: Environmental Phthalate Toxicity in the Immune System

Project Leader, Jennifer Schlezinger (Boston University School of Public Health)
Determining the molecular mechanism by which individual and complex mixtures of environmental chemicals impair the development of the mammalian immune system.

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Project 5: Mechanism and Impacts of Dioxin Resistance in Fish

Project Leader, Mark E. Hahn (Woods Hole Oceanographic Institution)
Understanding mechanisms underlying differential sensitivity to the developmental toxicity of halogenated aromatic hydrocarbons (HAHs) that act through the aryl hydrocarbon receptor (AHR).

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Project 6: CYP Genes and Developmental Toxicity

Project Leader, John J. Stegeman (Woods Hole Oceanographic Institution)
Continuing research in fish to understand the role of cytochrome p450 (CYP) enzymes in toxicity of chemicals during development.

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Project 7: Environmental Chemical-Gene Interactions in the CNS

Project Leader, Gloria V. Callard (Boston University, Department of Biology)
Investigating the hypothesis that environmental estrogens and dioxins are neurotoxicants by virtue of their ability to disrupt neural estrogen signaling and gene expression during neurodevelopment.
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Project 8: Endocrine Disrupting Effects in a Sentinel Species

Project Leader, Ian P. Callard (Boston University, Department of Biology)
Examining the components of the hypothalamic-pituitary-gonadal-target organ axis in the fresh-water turtle to determine the site(s) of lesion(s), which cause a demonstrated reproductive deficit in animals in a pond affected by a Superfund site.

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Project 9: Biomimetic Remediation of Hazardous Substances

Project Leader, Pericles Stavropoulos (University of Missouri-Rolla)
Providing new and more robust members of a family of mono-iron reagents (P-450 analogs) for remediation of groundwater and soils/sediments contaminated with halogenated and non-halogenated organics of suspected reproductive and developmental consequences.
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Administrative Core

Project Leader, David M. Ozonoff (Boston University School of Public Health)
Facilitating collaborations between projects and cores.
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Bioinformatics Core

Project Leader, Sandor Vajda (Boston University, Department of Biomedical Engineering)
Offering computational tools, expertise, and help to certain projects in modeling and analysis of microarray data.
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Community Outreach Core

Project Leader, Madeleine Scammell (Boston University School of Public Health)
Seeking to establish collaborative projects with communities, health care providers, and investigators to address environmental health problems related to community exposure to hazardous waste; and to increase public awareness about environmental health problems and solutions.
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Research Translation Core

Project Leader, Madeleine Scammell (Boston University School of Public Health)
Developing mechanisms to communicate with government agencies, to identify and transfer technology developed in the SRP to appropriate stakeholders, and to communicate research findings to broad audiences.
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Training Core

Project Leader, Ian P. Callard (Boston University, Department of Biology)
Facilitating student training, coursework, and distance learning for graduate students in these areas.
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